Endocrine Abstracts

ObjectivePresentation of multinodular goiter as an unusual feature in a patient with Williams-Beuren Syndrome.MethodsReview of the patient’s clinical records and of the relevant literature.IntroductionThe Williams-Beuren Syndrome is a multisystem disorder caused by a microdeletion of 1.5–1.8 megabase pairs on chromosome 7q11-123, with loss of 26–28 ...

Journal of Molecular Endocrinology, 2019, 64(1): 13–27 (DOI: https://doi.org/10.1530/JME-19-0158)...

Introduction: Delayed puberty is a common indication for referral to paediatric endocrine services. Although guidelines exist for management of testosterone replacement in adults, currently it is not clear what the optimum regimen for testosterone therapy is for children or how best to monitor boys throughout treatment.Aims: To identify the characteristics of testosterone therapy in boys referred for delayed puberty.Methods: Retros...

Introduction: Obesity is a pathological condition characterized by a low-grade systemic inflammatory state that predisposes to the onset of some diseases, such as hypertension, diabetes, and hyperlipidemia. Also, obesity can impact bone metabolism, but its effects are controversial.Aims: This observational study aimed to evaluate and correlate the bone mass with the lipidic profile, adipocytokines, glucose metabolism, hepatic function and purine metaboli...

Background and aims: Transition of patients with type 1 diabetes (DM1) from pediatric to adult care is challenging and international guidelines recommend effective transition programs. The aim of this study is to describe our baseline situation, without a structured transition program, and to identify factors associated with worse glycemic outcome.Materials and Methods: This is an observational, retrospective study of patients with DM1, aged 14 or more o...

Objectives: Hürthle cell (oncocytic) lesions can be metaplastic or neoplastic events. The neoplastic entities -formerly, oncocytic variant of follicular tumours; Hürthle cell neoplasm (HCN) - include HC adenomas and HC carcinomas and have been recognized as a separate class of tumours by the WHO. The remaining of the thyroid tumours demonstrating “mitochondrion-rich cells” and oncocytic morphology are referred under the umbrella term of “oncocytic vari...

Obesity is associated with peripheral and central low grade inflammation characterized by the increase in pro-inflammatory cytokines, such as tumor necrosis factor alpha (TNF). Phosphodiesterase 4 (PDE4) modulates the inflammatory responses and its inhibitor can strongly reduce TNF release and inflammation. Additionally, PDE4 knockout mice were shown to be resistant to diet-induced obesity (DIO). The aim of this study was to investigate the role of central and peripheral effec...

Introduction: The anatomical and physiological changes induced by bariatric surgery (BS) can significantly impact the absorption and pharmacokinetics of orally administered medication. In particular, levothyroxine (LT4) dosage, given its dependence on patient’s weight and gastric pH for optimal absorption, is expected to change following BS. However, the literature is not unanimous and there is a void of longer-term studies. We aimed to compare LT4 dosage 4 years followin...

Introduction: In Spain, the specialist in endocrinology and nutrition is the reference in the care of patients with diabetes mellitus. In the year 2022, access to these specialists has been facilitated in the south of Gran Canaria. The aim of the study is to determine how this has influenced the management of type 2 diabetes (T2D).Methods: We included those patients with T2D assessed by the Endocrinology service in 2022 in which two analyses were perform...

Introduction: Primary thyroid lymphomas (PTL) account for 5% of all thyroid malignancies. Treatment and prognosis depend on tumor subtype. Contrasting with diffuse large B-cell lymphomas (DLBCL), that have an aggressive clinical course and higher maximum standardized uptake value (SUVmax) in Fluorine-18-fluorodeoxyglucose positron emission tomography (FDG-PET), thyroid extranodal marginal zone B-cell lymphomas of mucosa-associated lymphoid tissue (MALT) usually show an indolen...